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Here at fandom_grammar, we've covered commas several times in the past, so I won't necessarily rehash that information here.
Anyone that knows me knows that I'm a stickler for the Oxford comma. But when I first saw this graphic, I nearly died from laughing so hard. I could picture the pauses with each comma. Of course, it didn't help -- or is that hurt? -- that I could also hear Walken's and Shatner's voices in my head as I was reading their panels.
I suppose this graphic, while hilarious, just illustrates the point of choosing your comma style and being consistent in its usage.